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Phenylketonuria (PKU) is a genetic disorder caused by a deficiency in the enzyme phenylalanine hydroxylase (PAH). This enzyme is responsible for converting the amino acid phenylalanine into tyrosine, another amino acid. In individuals with PKU, the inability to metabolize phenylalanine leads to its accumulation in the blood and brain. High levels of phenylalanine can cause __________ ________ ____ ___ ___ _________ __________ ____.
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