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The glutamate family of amino acids includes glutamate itself, as well as its derivatives, such as glutamine, proline, and arginine. The biosynthesis of these amino acids primarily begins with α-ketoglutarate, an intermediate of the citric acid cycle. Glutamate is synthesized by the enzyme glutamate dehydrogenase (GDH), which catalyzes the reductive amination of α-ketoglutarate using ammonia and NADH as cofactors. This reaction results in the formation of glutamate. Once glutamate is synthesized, it can be converted into other amino acids of the glutamate family through various pathways. Glutamine, _________ ____ ________ ____ ______ _____ ___ ________ ______ ______ ________.
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