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Purine catabolism in humans involves the sequential degradation of adenine and guanine nucleotides to uric acid, and xanthine oxidase plays a central role in the final oxidative steps of this pathway. Purine nucleotides are first converted into their corresponding nucleosides and free bases through dephosphorylation and deamination reactions. Adenine is deaminated to hypoxanthine, while guanine is directly deaminated to xanthine. Xanthine _______ _________ __________ __________ __________ ____ ______ ________ ______ _________.
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