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Purine nucleotides are synthesized de novo through a complex biochemical pathway that starts with simple precursors, ultimately forming the purine ring structure. The process occurs primarily in the liver and involves the sequential addition of atoms to a ribose sugar, resulting in inosine monophosphate (IMP), which serves as a precursor for both adenine and guanine nucleotides. The de novo synthesis of purine nucleotides begins with the activation of ribose-5-phosphate, a product of __________ _______ __________ _______ ________.
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