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De novo pyrimidine nucleotide biosynthesis is tightly regulated to maintain balanced nucleotide pools required for DNA replication, RNA synthesis, and cellular growth. Regulation mainly occurs at the early committed steps of the pathway through feedback inhibition, feed-forward activation, allosteric modulation, covalent modification, and coordination with cellular growth signals and cell cycle status. The overall goal of regulation is to match pyrimidine production with cellular demand and prevent wasteful overproduction. The most important regulatory step in eukaryotes occurs at carbamoyl phosphate synthetase _________ ______ ____ _____ _______ ________ ________ __________ __________ ___.
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