Question

What is SCID? Describe its classification, diagnosis and symptoms.

03 Feb 2026
Answer :
Word Count : 458
Severe Combined Immunodeficiency (SCID) is a group of rare, inherited disorders characterized by profound defects in both humoral and cell-mediated immunity. It results from impaired development and function of T lymphocytes along with variable defects in B lymphocytes and natural killer (NK) cells. Because of this combined immune deficiency, affected individuals are extremely susceptible to recurrent, severe, and often life-threatening infections from early infancy. SCID represents a medical emergency and is often fatal within the first year of life if untreated. SCID is classified based on the pattern of lymphocyte involvement and the underlying genetic or metabolic defect. One major classification is T⁻B⁺NK⁻ SCID, commonly caused by mutations in the interleukin-2 receptor gamma chain _______ ____ _________ ________ _________ _________ _______ ____.
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