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Transcription in eukaryotes is a highly regulated process involving multiple proteins that ensure precise initiation of gene expression. Central to this process are transcription factors, which can be broadly categorized into general (or basal) transcription factors and specific transcription factors. General transcription factors (GTFs) are essential for the transcription of all protein-coding genes by RNA polymerase II. They assemble at the core promoter region to form the pre-initiation complex (PIC), providing a platform for RNA polymerase II binding and accurate transcription initiation. Key general transcription factors _________ _________ ______ _______ __________.
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