What are the primary, secondary, tertiary, and quaternary structures of proteins? Provide examples and explain their significance in protein functionality.

Proteins are complex macromolecules essential for life, performing a wide range of biological functions. Their functionality is largely determined by their structure, which is organized into four levels: primary, secondary, tertiary, and quaternary structures. Each level of protein structure is crucial for its biological activity and stability.  

### Primary Structure  
The primary structure of a protein refers to its linear sequence of amino acids linked by peptide bonds. This sequence is dictated by the genetic code and determines how the protein will fold into its final functional form. Even a single change ___ ___ _____ ___ __________ ________ _______ _________ ___ _______.
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