Discuss the role of vitamins as coenzymes in metabolic reactions. Choose three vitamins and describe their biochemical roles and deficiency symptoms.

Vitamins play a crucial role in metabolism by serving as coenzymes or precursors to coenzymes that facilitate enzymatic reactions. Coenzymes are organic molecules that bind to enzymes and assist in catalysis, often by acting as carriers of specific atoms or functional groups. Many vitamins are modified within the body to form active coenzyme derivatives that participate in various biochemical pathways.  

### Vitamin B1 (Thiamine) and its Role in Metabolism  
Thiamine (Vitamin B1) is essential for carbohydrate metabolism. It is converted into thiamine pyrophosphate (TPP), which serves _____ _________ ___ ________ ____ ____ ________ _______ ______.
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