Explain the role of post-translational modifications in proteins. Provide examples of modifications like phosphorylation and glycosylation.
Post-translational modifications (PTMs) play a crucial role in determining the function, stability, localization, and interactions of proteins. These modifications occur after the translation process and involve covalent changes to amino acid residues in a protein. PTMs regulate various cellular processes, including signal transduction, enzymatic activity, protein-protein interactions, and immune responses. They can influence protein folding, degradation, and subcellular localization. PTMs also serve as regulatory switches, allowing proteins to rapidly respond to environmental or cellular signals.
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