Explain the role of constituent enzymes of pyruvate dehydrogenase complex involved in the conversion of pyruvate into acetyl-CoA.

The pyruvate dehydrogenase complex (PDC) is a multi-enzyme system that catalyzes the irreversible conversion of pyruvate into acetyl-CoA, linking glycolysis to the citric acid cycle. It consists of three core enzymes, each playing a distinct biochemical role in oxidative decarboxylation:

1. Pyruvate Dehydrogenase (E1): This enzyme catalyzes the first step, where pyruvate undergoes ___ _____ ________ ____ ________ _____.
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