Give a comparative account of purine and pyrimidine nucleotide degradation.

Purine and pyrimidine nucleotide degradation pathways differ significantly in their enzymes, intermediates, and end products.  

Purine Nucleotide Degradation:  
Purine nucleotides (adenosine monophosphate, AMP, and guanosine monophosphate, GMP) undergo dephosphorylation by nucleotidases to form nucleosides (adenosine and guanosine). Adenosine is further deaminated by adenosine deaminase to inosine, while guanosine is directly hydrolyzed to guanine. Inosine and guanosine undergo cleavage by purine nucleoside ___ ___ _________ ______ ________ ____.
_______ __________ __________ _______ ________ _________ ___ ________ ___.
____ _________ ________ __________ _______ ________ _____ ________ ______ ________.
____ ____ _______ _____ _______ _____ ________ ___ _________ ____ ______ ________.
________ ___ ________ _________ _____ ______ __________ ____ ____ ____ ________.
______ ______ ________ _________ ________ ___ ________ _______ _________ ___.
_____ __________ ____ ____ ___ __________ ___ _______ _____.
_______ _____ _____ ______ ______ ______ _______ _______.
_________ __________ _____ _____ _____ ______ ___ _____ __________ _____ ________.
____ __________ ___ _________ ___ ____ ____ _____.
______ ____ __________ _____ ____ ____.
__________ ____ ________ _________ ________.
____ ___ ___ _______ _____ _______ ____.
________ ______ ____ ____ ____ ___ ___.
____ ___ _____ ____ _________ ______ ____.
___ _______ _________ __________ _____ __________ ________ _________ ________ _________.
_______ _____ ____ ___ __________ _____ _____ _______ _______ ____ _______ _____.
____ ___ __________ ____ __________.
_________ ______ ______ ___ ______ __________ ______ _______ _________ _________ _________.
_____ _____ ________ ___ ____ ______.
___ _____ ___ ___ ___ ________ __________ _______ _________ ____ __________.
_________ ___ _________ ________ _________ ____ _____ ______ _________ __________ __________.
Get Full Answer on WhatsApp