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Spontaneous mutations are naturally occurring changes in the DNA sequence that arise without any external influence. These mutations often result from intrinsic cellular processes, such as errors during DNA replication, spontaneous chemical changes in nucleotide bases, or structural instability of the DNA molecule. One major source of spontaneous mutations is DNA replication errors, where DNA polymerase incorporates an incorrect nucleotide during the replication process. Although proofreading mechanisms exist, occasional mismatches escape correction, leading to permanent base pair changes in ___ ________ ____ ____ ______.
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