कंप्यूटर-सहायता प्राप्त औषधि डिजाइन में जैवसूचना विज्ञान उपकरणों और डेटाबेस के उपयोग का वर्णन करें, संरचना-आधारित और लिगैंड-आधारित दृष्टिकोणों पर प्रकाश डालते हुए। 

अनुक्रम विश्लेषण में PAM और BLOSUM जैसे अमीनो अम्ल प्रतिस्थापन मैट्रिक्स की संरचना और महत्व की व्याख्या कीजिए। 

युग्म–वार और बहु–अनुक्रम संरेखण के सिद्धांतों का वर्णन कीजिए और वैश्विक और स्थानीय संरेखण के बीच अंतर स्पष्ट कीजिए। 

अनुक्रम विश्लेषण में समानता, पहचान और समरूपता को परिभाषित कीजिए और अनुक्रम संरेखण में उनके महत्व की व्याख्या कीजिए। 

उपयुक्त उदाहरणों के साथ जैविक डेटाबेस को प्राथमिक, द्वितीयक और मिश्रित डेटाबेस में वर्गीकृत कीजिए। 

जैवसूचना विज्ञान के दायरे की व्याख्या कीजिए और जीनोमिक्स, प्रोटिओमिक्स और सिस्टम बायोलॉजी में इसकी भूमिका का वर्णन कीजिए। 

A building fetches a gross rent of Rs. 87500/- per month. Assuming: 31.2% outgoings for taxes, 15% for repair and maintenance and 5% to set aside to accumulate the cost of buildings; determine its capitalized value at 6.5% per annum. Also calculate its depreciated value after 40 years assuming a depreciation of 1% per annum on its value at beginning of every year.

Discuss the significance of "Case Laws" in valuation of a property

Explain various factors affecting valuation of land.

Critically examine the role of specifications in quality control.

State the features of the software relating to analysis of rates in a building project, that you may have come across or else you may collate the information as available on the world wide web on some relevant software and discuss its feature and limitations, if any.

Explain the uses of computer in tender document preparation

Discuss the various factors influencing the accuracy of estimates in building construction.

Calculate the carpet area of a building having a plinth area of 2100 m² It may be assumed that 30% of the built-up area will be taken by the corridors, verandah, lavatories, staircases, etc. and 10% of the built up area will be occupied by walls. Also prepare a preliminary estimate of this building. It is given that:

(i) Plinth area rate                                                                     Rs. 1700 per m²

(ii) Extra for special Architectural treatment                              2% of building cost

(iii) Extra for water supply and sanitary Installations                 5% of building cost

(iv) Extra of internal electric installations                                 20% of building cost

(v) Extra for other services                                                         5% of building cost

(vi) Contingencies                                                                      4% of overall cost

(vii) Supervision charges                                                            8% of overall cost

What do you mean by thermal insulation? Explain its significance. Also, list the materials used in providing thermal insulation.

 Explain the different materials used to clad the internal walls of any building. Also, list the benefits of cladding of walls.

Discuss the various factors on which depth of foundation of a multistoried building depends.

Describe the general requirements of "Hazardous Buildings". Also explain the important points to be considered in the planning of these buildings.

 Describe the materials used in the application of water proofing layers on thatched roofs. Also comment on the expected costs justifying its viability.

Discuss the minimum standards for rural housing as prescribed by NBO.