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Yeast Artificial Chromosomes (YACs) are engineered DNA molecules used as vectors to clone large fragments of eukaryotic DNA in yeast cells. They are derived from the natural chromosomes of *Saccharomyces cerevisiae* and retain essential chromosomal elements such as a centromere (CEN), telomeres (TEL), and an autonomously replicating sequence (ARS). These elements enable the YAC to replicate and segregate like a natural yeast chromosome ______ _______ _________ ______ _____ _________ ____ ___ __________ _____ ________.
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