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Enantioselectivity in alkylation reactions refers to the preferential formation of one enantiomer over the other when a prochiral substrate undergoes nucleophilic substitution or addition. Controlling enantioselectivity is essential in organic synthesis, particularly for producing biologically active compounds, as enantiomers often exhibit drastically different pharmacological properties. One common strategy involves the ______ ___ _______ __________ ______ _________ ____ __________ ________ ___ ________ ____.
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