What are the issues raised by patenting of onco-mouse?

The granting of an American patent in 1988 concerning the transgenic mouse or Harvard (Onco-) Mouse was very controversial and gave rise to a very strong, emotional reaction in the US, even though the USPTO only applied an earlier Supreme Court decision in the Diamond versus Chakraborty case of 1980, concerning a genetically modified bacteria used for the degradation of hydrocarbons.

When the European Patent Office had to examine the Harvard case, its first decision was a rejection of the patent application, on July 14, 1989; the grounds for this rejection were articles 53(b) (non-patentable subject matter) and 83 (insufficiency of disclosure). Article 53(a) (violation of ordre public and morality) was only cited by the Examining Division but was not specified as a __________ _______ _______ _________ ________ ____.
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