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The Strain and Distortion theory of enzyme catalysis is a concept that explains how enzymes increase the rate of chemical reactions by inducing a change in the substrate's structure. According to this theory, when a substrate binds to the enzyme's active site, it is not merely held in place; the enzyme actively distorts or strains the substrate molecule. This distortion brings the substrate closer to the transition state, which is the ______ ____ ___ ______ ________ __________.
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