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Proteins derive their biological activity from their specific three-dimensional conformations, which are determined by their primary sequence and stabilized through secondary and tertiary structural interactions. The secondary structure, consisting mainly of alpha-helices and beta-pleated sheets, is stabilized by hydrogen bonds between backbone atoms. The tertiary structure represents the overall three-dimensional folding of a single polypeptide chain, maintained by interactions such as hydrogen _________ _____ ____ __________ _______ _______ ________.
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