Question
Explain how alterations in protein secondary or tertiary structure can lead to loss of biological activity.
Answer :
Word Count : 264
Proteins acquire their biological activity from their specific three-dimensional structure, which is determined by the folding of the polypeptide chain into secondary and tertiary levels of organization. The secondary structure refers to local folding patterns such as alpha helices and beta pleated sheets, stabilized mainly by hydrogen bonds between the backbone atoms. The tertiary structure represents the overall three-dimensional conformation formed by interactions among side chains, ______ __________ __________ _______ _____ ___ __________ _____ ______.
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Proteins acquire their biological activity from their specific three-dimensional structure, which is determined by the folding of the polypeptide chain into secondary and tertiary levels of organization. The secondary structure refers to local folding patterns such as alpha helices and beta pleated sheets, stabilized mainly by hydrogen bonds between the backbone atoms. The tertiary structure represents the overall three-dimensional conformation formed by interactions among side chains, ______ __________ __________ _______ _____ ___ __________ _____ ______.
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