Draw TCA cycle indicating its enzymes, coenzymes/cofactors. How is it regulated?

The Tricarboxylic Acid (TCA) cycle, also known as the Krebs cycle or Citric Acid cycle, is a key metabolic pathway that plays a central role in cellular respiration. It takes place in the mitochondria of eukaryotic cells and is crucial for the generation of energy in the form of ATP. The TCA cycle is involved in the oxidation of acetyl-CoA to produce CO2, reducing equivalents (NADH and FADH2), and a small amount of ATP (or GTP, depending on the organism). These products are then used in the electron transport chain to produce ATP.

Enzymes and Coenzymes in the TCA Cycle

The TCA cycle consists of eight enzyme-catalyzed reactions, which can be broken down as follows:

1. Citrate Synthase: The first enzyme of the cycle catalyzes the condensation of acetyl-CoA with oxaloacetate to form citrate. This reaction requires water and releases CoA.

2. Aconitase: The second enzyme catalyzes the isomerization of citrate to isocitrate through the intermediate cis-aconitate. This reaction involves _________ ______ ______ ______ ________ _______ __________ _________ ___.
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