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With increasing age, the human endocrine system undergoes gradual changes that influence physical, mental, and metabolic health. These hormonal changes are not abrupt but progressive, reflecting the biological process of aging. The decline in hormone secretion, receptor sensitivity, and feedback mechanisms alters homeostasis and contributes to age-related disorders. One of the most studied changes is in the hypothalamic-pituitary axis, where regulatory control becomes less efficient, resulting in reduced hormonal output in several glands. In both men and women, sex hormones show marked changes. In women, menopause typically occurs between the ages of 45 and 55 years, ________ _______ __________ ______ _________ _______ __________ _______ ____ ______ _______.
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