Describe the regulation of pyruvate dehydrogenase complex by product inhibition.

Pyruvate dehydrogenase complex (PDC) plays a crucial role in cellular metabolism, linking glycolysis to the citric acid cycle by converting pyruvate to acetyl-CoA. The activity of PDC is tightly regulated to ensure metabolic balance. One key _____ __________ ____ ___ __________ _________ ____ _________ ___ ____ __________ ______.
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