b) Write the mechanism of Friedel-Craft’s alkylation. What are its limitations?
Friedel-Crafts alkylation is a widely used method in organic chemistry to introduce alkyl substituents onto aromatic rings. The mechanism involves the electrophilic substitution of an alkyl group onto an aromatic ring catalyzed by a Lewis acid, typically aluminum chloride (\(AlCl_3\)) or ferric chloride (\(FeCl_3\)). Here's a simplified mechanism:
1. Formation of the Electrophile: The alkyl halide (R-X) reacts with the Lewis acid catalyst to form a complex in which the halogen is activated as ___ ________ ________ _____ __________ ___ ______ _______ ___ _________.
_____ __________ ________ ____ ________ ________ _________.
___ _____ __________ _________ __________ __________ ________.
________ _____ ____ _________ ________ __________ __________ __________.
______ _____ ___ ___ ________.
__________ _________ _________ ____ _________.
________ _________ _________ ____ _____ ______ _________ _______ _____ ________ __________ __________.
_________ ___ __________ ____ _________ __________.
____ _______ _______ _____ _____ ________ _________ _________ ______ ____ ________.
________ _________ __________ ________ __________ ________ _______ ______ ____ __________ _____ ________.
_____ _____ _______ ____ _______ _________ ___ ______ ____ ________ ________ ________.
__________ ____ _________ _______ _______ _______ __________ _________ ___ _________.
___ _________ _____ ___ ________ ______ ____.
_____ __________ ___ ____ _________ ___ ____ ________ _____.
____ _____ ________ ___ ______ __________ ____.
____ _________ ____ _____ ___ ________ _____ ______ __________ ___ _______.
___ _______ _________ _________ ____ _____ ____.
_______ _____ ___ __________ ________ ___ ___ __________ _________ ________ ___ _______.
______ _________ _____ ______ __________ _______ __________ ____ _________.
________ __________ ______ _________ ___ ___ __________ _____ ___ ____ ________ _____.
___ _______ __________ ___ _________ ___ ___ _________ ________ _______ ____.
_____ __________ ____ ___ ________ __________ _______ ________ __________ _______.
___ __________ _______ ______ __________ _________ __________ __________ ________ __________ ___.
____ __________ ______ _______ ______ ______ ________ ____ ______.
____ __________.
Get Full Answer on WhatsApp