Question

Among alkyl halides, order of reactivity of SN2 reaction is

CH3X > p-RX > Sec-RX > tert-RX

Discuss the factors which are mainly responsible for this order. 

22 Jan 2025
Answer :
Word Count : 398

In an SN2 (Substitution Nucleophilic Bimolecular) reaction, the reactivity of alkyl halides is influenced by several factors, including the structure of the alkyl group, the leaving group, and the solvent. The order of reactivity for alkyl halides in an SN2 reaction is:

CH3X > p-RX > Sec-RX > tert-RX

The factors responsible for this reactivity order are:

  1. Steric Hindrance:

    • In SN2 reactions, the nucleophile attacks the electrophilic carbon center from the opposite side of the leaving group. The less sterically hindered the carbon center, the easier the nucleophile can approach and attack.
    • CH3X (methyl halide) has ______ ____ ______ ____ ________.
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