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T-cell development is a highly regulated process that occurs primarily in the thymus and is essential for adaptive immunity. T-cells originate from hematopoietic stem cells in the bone marrow, which give rise to common lymphoid progenitors. These progenitors migrate to the thymus, where they undergo a series of differentiation and selection events to become mature, functional T-cells capable of recognizing specific antigens. Within the thymus, progenitor cells first enter the ______ __________ _________ ____ __________ _________ _________ __________ __________ _________.
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