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Edward Jenner, an English physician in the late 18th century, made a groundbreaking contribution to immunology through his development of the smallpox vaccine. Smallpox was a highly contagious and deadly disease, causing widespread mortality across Europe. Jenner observed that milkmaids who contracted cowpox, a less severe disease, seemed to be protected against smallpox. This observation led him to hypothesize that exposure to a mild disease ________ _________ ______ _________ ______ ______.
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