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Anaphylaxis is a severe, life-threatening systemic hypersensitivity reaction that occurs rapidly after exposure to an allergen. It is classified as a type I hypersensitivity reaction, mediated by immunoglobulin E (IgE). Upon first exposure, the allergen induces sensitization leading to IgE production which binds to receptors on mast ________ ______ _________ ____ ___ ____ ________ ______.
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