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The Boots synthesis of ibuprofen is an important example often discussed in the context of green chemistry because it demonstrates a relatively efficient and selective pharmaceutical synthesis. The process begins with isobutylbenzene as the starting material. In the first step, isobutylbenzene undergoes Friedel–Crafts acylation with acetyl chloride in the presence of a Lewis acid catalyst such as aluminium chloride to form p-isobutylacetophenone. This ___ __________ _________ ______ ________ _______ __________ _____ ______ ___.
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