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Adult hookworms residing in the human intestine induce a complex immune response that involves both humoral and cellular components, although the parasite has evolved mechanisms to evade complete elimination. The immune response is typically biased toward a Th2-type profile, which is characteristic of helminth infections and plays a significant role in limiting parasite burden and associated pathology. The humoral immune response against adult hookworms is marked by the production of specific antibodies, particularly IgE, IgG, and IgA. IgE plays a central ______ ___ ________ ________ _____ __________.
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