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The kidney is particularly susceptible to nephrotoxicity due to its unique structure, high blood flow, and role in concentrating and excreting xenobiotics. Renal tubular cells, especially in the proximal tubules, actively uptake and metabolize chemicals, exposing them to higher concentrations of potentially toxic substances. The kidney’s function of concentrating urine can increase the local concentration of nephrotoxicants, ____ _______ _________ _____ _________ ________.
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