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Selective organ toxicity occurs when toxicants have a greater harmful effect on certain organs or tissues than others. This selective targeting can be influenced by several factors related to both the properties of the toxicant and the characteristics of the organs involved. The first factor is the chemical structure and reactivity of the toxicant. Some toxicants are more likely to accumulate or interact with specific biological molecules in certain tissues, leading to localized toxicity. For instance, the liver, with its high metabolic activity and detoxification role, is a common target for chemicals that are metabolized by cytochrome P450 enzymes, which may activate or transform these substances into harmful metabolites. Another reason for selective toxicity is the blood flow to specific organs. Organs ________ _______ ______ ___ _________.
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