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Cell Mediated Immune System (CMIS) is the branch of the adaptive immune system that protects the body against intracellular pathogens such as viruses, certain bacteria, fungi, parasites, and abnormal cells including cancer cells. Unlike humoral immunity, which is mediated by antibodies produced by B lymphocytes, CMIS primarily depends on T lymphocytes, macrophages, natural killer (NK) cells, antigen-presenting cells (APCs), and cytokines. It is particularly effective in eliminating infected host cells and providing long-term immunological memory. Cell-mediated immunity plays a vital role in organ transplant rejection, delayed hypersensitivity reactions, tumor surveillance, and defense against microorganisms that survive within host _____ _______ ________ ____ ________ ______ ______ _________.
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