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The Cell Mediated Immune System (CMIS) is a major component of the adaptive immune system that provides protection against intracellular pathogens such as viruses, certain bacteria, fungi, parasites, and abnormal cells including cancer cells. Unlike humoral immunity, which is mediated by antibodies produced by B lymphocytes, CMIS primarily depends on T lymphocytes and other immune cells to recognize and destroy infected or abnormal cells. It is especially important when pathogens enter and multiply inside host cells, where antibodies cannot easily reach them. Cell-mediated immunity also plays a significant role in graft rejection, delayed hypersensitivity __________ _____ _______ ________ ________ _________ _________ ___ ____ _________ ______ ________.
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