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Supramolecular reactivity and catalysis involve molecular interactions that occur through non-covalent forces such as hydrogen bonding, π–π stacking, van der Waals forces, electrostatic interactions, and hydrophobic effects. The process generally follows several important steps. The first step is substrate recognition, where the host molecule identifies and selectively binds the substrate through complementary shape, size, and intermolecular interactions. This molecular recognition is crucial for ensuring ___ ____ ____ _______ __________ _________ ______ ____ ______ _______ ____.
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