What are the ethical and biosafety concerns while doing rDNA experiments?

Recombinant DNA (rDNA) technology, which involves manipulating the genetic material of organisms, has revolutionized biotechnology and medicine. However, it raises several ethical and biosafety concerns.

One major ethical issue is the potential for unintended consequences, especially in genetic modifications of humans, animals, or plants. There is a fear of "designer ___ _____ ___ ______ _____.
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