What are metal activated enzymes?

Metal-activated enzymes are a category of enzymes that require the presence of metal ions for their optimal activity. These enzymes do not have a permanently bound metal ion as a prosthetic group but instead rely on free metal ions from the surrounding medium to enhance their catalytic efficiency. The metal ions interact with the enzyme or substrate transiently and play a crucial role _________ __________ _____ ______ ________ ________ _________ _______ _____ _________.
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