Question
Show how you could synthesise the following compounds using acetoacetic ester/ malonic ester
Answer :
Word Count : 331
To synthesize the given compound (a substituted cyclohexanone derivative) using acetoacetic ester or malonic ester synthesis, we'll need to follow a multi-step approach. The target molecule appears to be 2-methylcyclohexanone with substituents at the 3-position. ### Using Acetoacetic Ester Synthesis: 1. Starting Material: Ethyl acetoacetate (acetoacetic ester) 2. Alkylation: - Deprotonate the α-hydrogen between the two carbonyl groups using a strong base (e.g., NaOEt). - React _______ ________ ____ _________ _____ _______ _________.
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To synthesize the given compound (a substituted cyclohexanone derivative) using acetoacetic ester or malonic ester synthesis, we'll need to follow a multi-step approach. The target molecule appears to be 2-methylcyclohexanone with substituents at the 3-position. ### Using Acetoacetic Ester Synthesis: 1. Starting Material: Ethyl acetoacetate (acetoacetic ester) 2. Alkylation: - Deprotonate the α-hydrogen between the two carbonyl groups using a strong base (e.g., NaOEt). - React _______ ________ ____ _________ _____ _______ _________.
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