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Janus kinase (JAK) is a type of intracellular non-receptor tyrosine kinase that plays a critical role in the signaling of many hormones and cytokines. Biochemically, JAKs are associated with the cytoplasmic domains of various cytokine and hormone receptors, including those ___ ______ _________ _____ ___ __________ _______ ___ ________ ____.
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