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Cyclic adenosine monophosphate (cAMP) is a critical second messenger in hormone signaling, mediating a wide range of physiological processes. Many hormones, particularly those that are water-soluble such as epinephrine, glucagon, and adrenocorticotropic hormone (ACTH), cannot directly cross the cell membrane. Instead, they bind to specific cell surface receptors known as _____ ________ ____ ______ ________ ________ ______.
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