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Methylmercury is a potent neurotoxin that primarily affects the central nervous system. Its neurotoxicity begins with its high affinity for sulfhydryl groups, particularly in proteins and enzymes critical for neuronal function. Methylmercury readily crosses the blood-brain barrier and accumulates in neurons and glial cells. Inside the neurons, it binds to thiol-containing proteins, disrupting their structure and function. This leads to oxidative stress by generating reactive oxygen ______ ____ _________ ___ ___ _________ _______ _________ _______.
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