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Selective organ toxicity of toxicants occurs due to various factors, including the distribution, metabolism, and specific interactions between toxicants and cellular components. One key factor is the selective accumulation of toxicants in particular organs, which can happen due to the affinity of these substances for certain tissues. For instance, the liver, kidneys, and lungs often accumulate higher concentrations of certain chemicals because of their roles in detoxification, filtration, and gas exchange, respectively. In the liver, enzymes involved in the biotransformation of toxicants, such as cytochrome P450, may activate substances into more reactive forms, which can then damage hepatocytes and other __________ _______ _____ ________ ____.
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