Question

Explain Negishi coupling reaction with an example and give its mechanism.

09 Jan 2025
Answer :
Word Count : 230

The Negishi coupling reaction is a type of cross-coupling reaction in organic chemistry, where an organozinc reagent is reacted with an organohalide in the presence of a palladium (Pd) catalyst to form a new carbon-carbon bond. This reaction is widely used in the synthesis of complex organic compounds due to its versatility and mild reaction conditions.

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