Discuss the concepts of “Substitution” in First Line ART. Describe the substitutions done in the National Programme.

In the context of HIV treatment, "substitution" refers to replacing one antiretroviral medication with another within the first line of antiretroviral therapy (ART). This strategy becomes necessary when a patient experiences adverse effects, drug interactions, or develops resistance to the initial ______ _____ ______ ________ ______.
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