What are Nucleoside Reverse Transcriptase Inhibitors (NRTI’s)? D

Question

What are Nucleoside Reverse Transcriptase Inhibitors (NRTI’s)? Discuss the mechanism of action, dosage and adverse effects of NRTIs used in the National Programme regimens.

10 Apr 2024

Answer :

Word Count : 416

Nucleoside Reverse Transcriptase Inhibitors (NRTIs) are a class of antiretroviral drugs used in the treatment of HIV infection. They work by interfering with the replication process of the HIV virus, specifically targeting the enzyme reverse transcriptase, which is essential for HIV replication.

Mechanism of Action:
NRTIs function by mimicking the structure of natural nucleosides, the building blocks of DNA and RNA. When the HIV virus attempts to replicate its genetic material, it incorporates these synthetic nucleosides into its DNA chain instead of the natural ones. However, once incorporated, NRTIs act as faulty substrates, halting the DNA synthesis process. This interruption prevents the completion ________ ___ ______ ____ ______ ___ ______ _____ ______.
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