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The application of green chemistry in pharmaceutical synthesis has greatly reduced environmental impact while maintaining efficiency. In the case of simvastatin, a cholesterol-lowering drug, traditional chemical synthesis involved multiple steps with toxic reagents and hazardous solvents. Green chemistry introduced enzymatic catalysis using engineered acyltransferases, which selectively catalyze esterification reactions under mild conditions, avoiding the need for toxic intermediates and reducing waste. For _______ ___ ______ ____ ______ _________ _____ ___ _________ ___ ____.
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