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The Boots synthesis of ibuprofen is a classical example of a multi-step process that highlights the application of green chemistry principles when later modified to reduce waste and improve efficiency. Originally developed in the 1960s by the Boots Pure Drug Company in the United Kingdom, the process begins with isobutylbenzene as the starting material. In the first step, Friedel–Crafts ___ ___ ____ ____ ___ ___.
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