Question

Discuss any two methods of preparation of oxetanes giving suitable examples.

01 Dec 2025
Answer :
Word Count : 242
Oxetanes are four-membered cyclic ethers characterized by significant ring strain, making them interesting intermediates in organic synthesis. One common method for preparing oxetanes is the intramolecular Williamson ether synthesis. In this approach, a haloalcohol undergoes base-induced cyclization. For instance, 3-chloropropanol treated with a strong base like sodium hydride or potassium tert-butoxide leads to nucleophilic displacement of the halide by the ___ _________ ____ ____ ___ _______ _______.
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