Discuss the disconnections for the synthesis of paracetamol. Also write its scheme of synthesis. Draw the general scheme/mechanism of Stille coupling reaction. Give examples of some additives which are used to increase the rate of these reactions.
The retrosynthetic analysis of paracetamol involves disconnecting the amide bond to yield *p-aminophenol* and *acetic anhydride* as key precursors. Further disconnection of p-aminophenol traces back to *p-nitrophenol*, which can be obtained from electrophilic nitration of phenol under controlled conditions to ensure para-selectivity. Subsequent reduction of the nitro group, generally ____ _______ ___ _________ __________ ___ __________ __________ ________ ______.
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) Vilsmeier-Haack reaction of benzofuran
give a general reaction of asymmetric 1, 2-aminohydroxylation of alkenes using (DHQ)2-PHAL AD catalyst in the presence of (TsNCINa). Also give various nitrene equivalents which are frequently as reagents in this reaction.
Benzimidazole reacts with formaldehyde
(i) Disimylborane
What are stereospecific reactions? Briefly discuss any two of their examples.
Discuss the sequence of reactions for preparing the following compound using ethylaceoacetate
Benzimidazole reacts with acrylonitrile