Discuss the disconnections for the synthesis of paracetamol. Also write its scheme of synthesis. Draw the general scheme/mechanism of Stille coupling reaction. Give examples of some additives which are used to increase the rate of these reactions.
The retrosynthetic analysis of paracetamol involves disconnecting the amide bond to yield *p-aminophenol* and *acetic anhydride* as key precursors. Further disconnection of p-aminophenol traces back to *p-nitrophenol*, which can be obtained from electrophilic nitration of phenol under controlled conditions to ensure para-selectivity. Subsequent reduction of the nitro group, generally by catalytic hydrogenation or metal–acid reduction, furnishes p-aminophenol. Acetylation of this amine using __________ _____ ________ ___ ________ ______ ______ ___ ___.
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Draw the products of the following:
(i) Reduction of quinoline with different reagents.
(ii) Oxidative cleavage of quinoline
(iii) Bromination of quinoline
How many signals will appear in the 1H-NMR of the following compounds?
Pyrizino [2,3-d] pyridazine
9-BBN
give a general reaction of asymmetric 1, 2-aminohydroxylation of alkenes using (DHQ)2-PHAL AD catalyst in the presence of (TsNCINa). Also give various nitrene equivalents which are frequently as reagents in this reaction.
Benzimidazole reacts with formaldehyde
Discuss the sequence of reactions for preparing the following compound using ethylaceoacetate
