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The extracellular matrix is a complex and dynamic network of macromolecules that occupies the space between cells in tissues and provides structural support, biochemical signals, and mechanical properties essential for tissue organization and function. It is not merely a passive scaffold but an active participant in regulating cell behavior such as adhesion, migration, proliferation, differentiation, and survival. The major components of the extracellular matrix include fibrous proteins, proteoglycans, glycosaminoglycans, and specialized adhesive glycoproteins, each contributing specific structural and functional ___ _____ ______ ____ _______ ____ _____ _______ _________ ______ ___ _____.
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