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The extracellular matrix is a complex and dynamic network of macromolecules that occupies the space between cells in tissues and provides structural support, biochemical signals, and mechanical properties essential for tissue organization and function. It is not merely a passive scaffold but an active participant in regulating cell behavior such as adhesion, migration, proliferation, differentiation, and survival. The major components of the extracellular matrix include fibrous proteins, proteoglycans, glycosaminoglycans, and specialized adhesive glycoproteins, each contributing specific structural and functional roles. Fibrous proteins form the structural framework of the extracellular matrix and provide tensile strength, elasticity, and resistance to mechanical stress. Collagen is the most abundant fibrous protein in the extracellular matrix and in the human body. It exists in ______ ____ ______ ____ ___ ________ _____ _______ ___ _________ __________ _______.
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